CTLA-4 gene polymorphism is associated with predisposition to coeliac disease
نویسندگان
چکیده
منابع مشابه
CTLA-4 gene polymorphism is associated with predisposition to coeliac disease.
BACKGROUND Susceptibility to coeliac disease is strongly associated with particular HLA class II alleles. However, non-HLA genetic factors are likely to be required for the development of the disease. Among candidate genes is the CTLA-4 (cytotoxic T lymphocyte associated) gene located on chromosome 2q33 in humans, which encodes a cell surface molecule providing a negative signal for T cell acti...
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OBJECTIVES Factors contributing to the development of systemic lupus erythematosus (SLE) remain largely unknown although are likely to include both environmental and genetic components. Studies on murine lupus have indicated a role for an antibody that blocks binding of cytotoxic T lymphocyte associated-4 (CTLA-4) to B7 on antigen presenting cells in the treatment of disease, suggesting that CT...
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ژورنال
عنوان ژورنال: Gut
سال: 1998
ISSN: 0017-5749,1468-3288
DOI: 10.1136/gut.43.2.187